فرایند چند مرحله اى با جریان متقابل براى استخراج گلیسیریزیک اسید از گیاه شیرین بیان

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری مهندسی شیمی ، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی

2 دکترای مهندسی شیمی، عضو هیئت علمی دانشگاه صنعتی شریف تهران

3 استاد انسیتو پاستور ایران

4 4- دانشیار، گروه مهندسی شیمی، دانشگاه آزاد اسلامی تهران جنوب

چکیده

در این تحقیق، عصاره ریشه شیرین بیان به روش استخراج چند مرحله‌اى با جریان متقابل در مقیاس بنچ، استخراج و میزان اسید گلیسیریزیک موجود در آن مورد بررسی قرار گرفت. تاثیر پارامترهای مختلف از جمله دما، زمان، تعداد مراحل استخراج و نسبت حلال ( اتانول و آمونیاک غلیظ ) به جامد ارزیابی شد. شرایط بهینه استخراج از طریق روش آماری سطح پاسخ تعیین گردید. نتایج تحلیل‌ آماری نشان داد که سه متغیر دما، زمان و تعداد مراحل استخراج تأثیر معنی داری بر باده استخراج دارند. براساس بهینه سازی با معیار بیشینه سازی پاسخ، شرایط بهینه به صورت زمان 98/5 ساعت، دمای 17/46 درجه سلسیوس، نسبت حلال به جامد cc/gr70/7، تعداد مراحل 4 به دست آمد. در این شرایط بازده استخراج گلیسیریزیک اسید 7/78 بود.

چکیده تصویری

فرایند چند مرحله اى با جریان متقابل براى استخراج گلیسیریزیک اسید از گیاه شیرین بیان

تازه های تحقیق

  • این مقاله بررسى آمارى و بهینه سازى شرایط فرایندى استخراج گلیسیریزیک اسید با استفاده از RSM به منظور حداکثر نمودن درصد گلیسیریزیک اسید انجام شد.
  • نتایج نشان مى دهد که مدل آمارى درجه دوم با دقت بالایى به منظور پیش بینى پارامترهاى پاسخ قابل استفاده است.
  • روش استخراج چند مرحله اى با جریان متقابل به عنوان یک فناورى کارآمد استخراج براى گیاهان دارویى با مصرف انرژى و حلال کمتر قابل استفاده است.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

A multi-stage counter-flow process for extracting glycyrrhizic acid from the licorice plant

نویسندگان [English]

  • Zeinab Azizi Haghighat 1
  • Aliakbar Seifkordi 2
  • Azim Akbarzadeh 3
  • Mehdi Arjmand 4
1 Department of Chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
2 Chemical Engineering Department, Sharif University of Technology, Tehran, Iran
3 Department of Pilot Nanobiotechnology, Pasteur Instiute of Iran, Tehran, Iran
4 Department of Chemical Engineering, South Tehran Branch, Islamic Azad University, Tehran, Iran
چکیده [English]

In this study, licorice root extract was obtained using a multi-stage countercurrent extraction method at bench scale, and the content of glycyrrhizic acid was investigated. The effects of various parameters including temperature, extraction time, number of extraction stages, and solvent-to-solid ratio were evaluated. The optimal extraction conditions were determined using response surface methodology (RSM). Statistical analysis revealed that temperature, time, and number of extraction stages had significant effects on the extraction yield. Under the optimized conditions temperature of 46.17 °C, extraction time of 5.98 hours, solvent-to-solid ratio of 7.70 cc/g, and 4 stages the maximum glycyrrhizic acid extraction yield was 78.7%.

کلیدواژه‌ها [English]

  • multi-stage countercurrent extraction. licorice
  • glycyrrhizic acid
  • response surface methodology
 
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دوره 13، شماره 2
بهمن 1404
صفحه 83-100
  • تاریخ دریافت: 02 اردیبهشت 1404
  • تاریخ بازنگری: 02 شهریور 1404
  • تاریخ پذیرش: 05 شهریور 1404
  • تاریخ اولین انتشار: 05 شهریور 1404
  • تاریخ انتشار: 01 بهمن 1404