نوع مقاله : مقاله پژوهشی
نویسندگان
1 گروه مهندسی شیمی-دانشکده فنی-دانشگاه گیلان
2 دانشگاه گیلان
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Naringin is an anti-oxidation and anti-cancer drug that is used for the synthesis of some important substances in the field of pharmaceutical and medical sciences. In this research, naringin substance is extracted from orange peel using ethanol solvent by ultrasonic method. Design-Expert (DOE) software was used to determine the optimal parameters including time, pH, and sample-to-solvent ratio while keeping the temperature constant at 40°C. The concentration and purity of naringin in the samples were measured using spectrophotometric and high-performance liquid chromatography (HPLC) analyses. According to DOE results, pH value had a greater effect on extraction efficiency compared to other parameters. The yield of naringin extraction was increased in less time and very weak acidic pH values. Naringin extraction reached the maximum value at the beginning of the process. Finally, the highest efficiency of naringin extraction was determined using 86.29% ethanol solvent at pH = 6.52, time 20 minutes, sample to solvent ratio 0.24, and extraction amount 123.27 mg/liter. The purity of naringin in the powder obtained from orange peel extract was measured as 88.20%. The ANOVA model for ethanol solvent showed a correlation coefficient of 0.96, which can be a suitable model for this extraction process.
کلیدواژهها [English]
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