استفاده از میکروهیدروژل های بارگذارى شده با نیوزوم و لیپوزوم در ریزپوشانی و رهش طولانی مدت ترکیبات کوچک مولکول آبدوست

نوع مقاله: مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری علوم و صنایع غذایی، پژوهشکده علوم و صنایع غذایی، مشهد

2 دانشیار، پژوهشکده علوم و صنایع غذایی، مشهد

3 استادیار، پژوهشکده علوم و صنایع غذایی، مشهد

چکیده

در این مطالعه سامانه هیدروژلی آلژینات کلسیم بارگذارى شده با نیوزوم ها و لیپوزوم ها به منظور ریزپوشانی کافئین به عنوان یک ترکیب زیست فعال آبدوست با وزن مولکولی پایین، با هدف طولانى کردن زمان رهش آن مورد استفاده قرار گرفت. به منظور بارگذارى لیپوزوم ها یا نیوزوم ها در شبکه آلژیناتى و کاهش اندازه هیدروژل از روش الکترواسپری در محلول کلرورکلسیم استفاده شد. چرخه های پیاپى انجماد-رفع انجماد نیز با رویکرد کند کردن آهنگ رهش کافئین بکارگرفته شد. نتایج گویای بالاتر بودن کارایی ریزپوشانی نیوزوم ها نسبت به لیپوزوم ها در به دام اندازی کافئین بودند. همچنین داده هاى سنجش آهنگ رهش بیانگر تأثیر مثبت چرخه هاى انجماد-رفع انجماد و کارامدتر بودن سامانه هیدروژل بارگذارى شده با نیوزوم در مقایسه با لیپوزوم بود. لیپوزوم های تولید شده از لسیتین با خلوص بالاتر در مقایسه با لسیتین تجاری کارایی درون پوشانی و الگوی رهش بهتری را از خود نشان دادند. نتایج مدل سازی ریاضی انتشار کافئین از ذرات هیدروژلى با توجه به مدل کورسمیر- پپاس مؤید پیروی آهنگ رهش از قانون انتشار فیک بود. بررسی ها نشان داد که میکروهیدروژل های بارگذارى شده با نیوزوم و لیپوزوم از قابلیت مناسبى در ریزپوشانی ترکیبات غذایی و دارویی آبدوست با هدف رهش بلند مدت برخودار مى باشند. همچنین مشخص شد که استفاده از روش الکترواسپری منجر به تولید ذراتی با توزیع اندازه یکنواخت می گردد و از این رو می‌تواند به عنوان جایگزینى براى روش هاى مرسوم تولید میکروذرات هیدروژلی از پلیمرهای طبیعی مورد توجه قرار گیرد.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Niosome- and liposome-loaded calcium alginate microhydrogels for encapsulation and sustainable release of hydrophilic low molecular weight compounds

نویسندگان [English]

  • Alireza Mehregan Nikoo 1
  • Rassoul Kadkhodaee 2
  • Behrouz Ghorani 3
1 Ph.D., Food Science and Technology, Department of Food Chemistry, Research Institute of Food Science and Technology (RIFST), Mashhad, Iran.
2 Associate Professor, Department of Food Nanotechnology, Research Institute of Food Science and Technology (RIFST), Mashhad, Iran
3 Assistant Professor, Department of Food Nanotechnology, Research Institute of Food Science and Technology (RIFST), Mashhad, Iran.
چکیده [English]

Calcium alginate microhydrogels loaded with niosomes and liposomes were used to encapsulate caffeine as a model low molecular weight hydrophilic bioactive compound. To load niosomes and liposomes into alginate hydrogel network and to reduce the size of gel particles the feed solution was electrosprayed into calcium chloride solution. Successive freeze-thaw cycles were employed with a view to slow the release rate of caffeine from niosomes and liposomes. The results showed that niosomes was more efficient in caffeine encapsulation than liposomes. The release profiles confirmed the positive effect of freeze-thaw cycles on sustainable release of caffeine and that the niosome-loaded hydrogels had slower rate of caffeine release. Also, liposomes made of highly pure lecithin revealed more encapsulation efficiency as well as better release profile compared to those of commercial lecithin. Korsmeyer-Peppasmodel was found to appropriately describe the release of caffeine from particles  based on Fickian diffusion. The findings of this study clearly demonstrated that niosome- and liposome- loaded microhydrogels could potentially be used to encapsulate food and pharmaceutical compounds for slow release applications. Moreover, electrospraying technique owing to its capability of producing uniform fine particles could be used as an alternative method for hydrogel preparation from natural polymers.

کلیدواژه‌ها [English]

  • Filled hydrogel
  • Liposome
  • Niosome
  • Caffeine
  • Electrospray
  • Encapsulation
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