Evaluation of Cellulose Acetate Nanofibers Morphology in Single and Binary Solvent Systems for Production of Edible Cyclodexterin Nanocarriers

Document Type : Research Article


1 Department of Food Nanotechnology, Research Institute of Food Science & Technology

2 Department of Food Nanotechnology,Research Institute of Food Science and Technology (RIFST)


The positive characteristics of nanofibers such as high surface area-to-volume ratio, appropriate flexibility of the functional group and superior mechanical performance, in cooperation with placing the cyclodexterins would provide an appropriate platform for the production of neutroceutical nanocarriers. Electrospinning as an easy and non-thermal method is a suitable choice in nanofiber production. Different factors influence the nanofiber production of which the solvent selection is of great importance. In this paper we aim to study the optimized solvent system for electrospinning of cellulose acetate polymer and cyclodexterin. In this way, the influence of single and binary solvent systems i.e. Dimethylformamide (DMF), Dimethylacetamide (DMAc), acetone: DMAc (1:2), acetone: DMAc (2:1), acetone: DMF (1:2), and acetone: DMF (2:1), on the morphology and the diameter of nanofibers was investigated. The embedment of cyclodexterin in the nanofiber structure was studied using the phenolphthalein absorption technique. The polymeric solutions showed a non- Newtonian pseudoplastic behaviour. The application of binary solvent system of acetone: DMF (2:1) at 20% (w/v) cellulose acetate polymer, 2% (w/v) cyclodexterin, under the processing condition 25 kV, 1.5 ml/h, and the needle to collector distance of 150 mm is suggested for the production of cyclodexterin nanocarriers.


Main Subjects

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