Production and evaluation of nanoliposomes containing nisin and natamycin by Mozaffari method

Document Type : Research Article


1 M.Sc. Student, Department of Food Science and Technology, Faculty of Agriculture, University of Tabriz, Tabriz, Iran

2 Assistant Professor, Department of Food Science and Technology, Faculty of Agriculture, University of Tabriz, Tabriz, Iran

3 Associate Professor, Department of Food Science and Technology, Faculty of Agriculture, University of Tabriz, Tabriz, Iran

4 Assistant Professor, Department of Pharamaceutical Science, Pharamaceutical Technology Laboratory, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


In this research, liposomes containing nisin and natamycin are produced by Mozaffari method.The concentrations of encapsulated nisin and natamaycin are determined using AutoAnalyzer and Spectrophotometry assay, respectively. Then, particle size and stability of liposomes over during time (70 days) in liposomes containing of polyethylene glycol and without it, are investigated. The results show that particle size and size distribution (span) is 76-90 nm and 0.73-0.9 nm. The encapsulation efficiency of nisin and natamaycin are 89-96% and 89-96%, respectively. The stability results indicate that formulations containing polyethylene glycol are stable during 70 days. The results show that polyethylene glycol for stabilizing liposomes can be used.


Main Subjects

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